Efficacy of rescue ICSI after total fertilization failure in conventional IVF

Partial or complete fertilization failure after IVF was reported in 5-10% of cycles. Total fertilization failure in patients with normal sperm parameters is rare but very stressful incident after IVF. To rescue the IVF cycles after total fertilization failure, ICSI of unfertilized oocytes after initial insemination has been reported.We reviewed a 2 years experience of rescue ICSI and analyzed the cycles outcomes. Cycles with total fertilization failure using mature oocytes with normal morphology, which had no evidence of fertilization 24 hours after IVF were selected for this study and reinsemination by ICSI was performed. 15 rescue ICSI cycles were included in our study. After rescue ICSI fertilization rate per cycle was 54.32%. Also 5.53±4.15 embryos were obtained and 2.54±o.34 embryos were transferred in each cycles. But no pregnancy was reported after fresh embryo transfer. This study showed that day1 rescue ICSI is not a good option for prevention of complete fertilization failure after IVF procedure.